Forschung
Das Institut für Pharmazeutische Technologie.

Stand: 04.10.2009

1. Publikationen in referierten Zeitschriften
2. Buchbeiträge
3. Proceedings, Abstracts, Kongressbeiträge
4. Dissertation

1. Publikationen in referierten Zeitschriften

2009

Hahne M., Reichl S.
Ophthalmologe (accepted for publication)
Simulation of corneal epithelial injuries via mechanic and corrosive damage and the influence of fetal bovine serum and dexpanthenol on epithelial regeneration in a cell culture model.

Wengst A., Reichl S.
European Journal of Pharmaceutics and Biopharmaceutics (accepted for publication)
RPMI 2650 epithelial model and three-dimensional reconstructed human nasal mucosa as in vitro models for nasal permeation studies.

Reichl S.
Biomaterials (in press)
Films based on human hair keratin as substrates for cell culture and tissue engineering.

Reichl S.
Pharmazeutische Zeitung (2009) 154:2987-2995
Moderne Arzneiformen für starke Analgetika.

Attama A., Reichl S., Müller-Goymann C.C.
Current Eye Research (2009) 34:698-705
Sustained release and permeation of timolol from surface modified solid lipid nanoparticles through bio-engineered human cornea.

2008

Reichl S.
J Pharm Pharmacol (2008) 60:299-307
Cell culture models of the human cornea - A comparative evaluation of their usefulness to determine ocular drug absorption in vitro.

Werner A., Braun M., Reichl S., Kietzmann M.
Vet Ophthalmol (2008) 11:280-289
Establishing and functional testing of a canine cornea construct.

Attama A., Reichl S., Müller-Goymann C.C.
Int J Pharm (2008) 355 (1-2): 307-313
Diclofenac sodium delivery to the eye: in vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct.

2005

Aintablian A., Reichl S., Bednarz J.
Augenspiegel 42 (09): 42-44
Entwicklung einer künstlichen Hornhaut für Keratoplastik.

Reichl S., Döhring S., Bednarz J., Müller-Goymann C.C.
Eur J Pharm Biopharm (2005) 60: 305-308
Human Cornea Construct HCC - an alternative for in-vitro permeation studies? A comparison with human donor corneas.

Meyer L., Bednarz J., Müller-Goymann C.C., Reichl S.
Ophthalmologe (2005) 102: 971-980
Esterase activity of human organotypic cornea construct - HCC as in vitro model for permeation studies.

Friedrich I., Reichl S., Müller-Goymann C.C.
Int J Pharm (2005): 305 (1-2): 167-175
Drug release and permeation studies of nanosuspensions based on solidified reverse micellar solutions (SRMS).

2004

Reichl S., Bednarz J., Müller-Goymann C.C.
Br J Ophthalmol (2004) 88: 560-565
Human corneal equivalent as cell culture model for in vitro drug permeation studies.

Tegtmeyer S., Reichl S., Müller-Goymann C.C.
Pharmazie (2004) 59: 464-471
Cultivation and characterization of a bovine in vitro model of the cornea.

Reichl S., Müller-Goymann C.C.
Pharmazeutische Zeitung (2004) 149: 1638-1644
Künstliche Hornhaut als In-vitro-Modell.

Friedrich I., Reichl S.
Vet-Med Report (2004) 28 V5: 7
Study on solubility and handling of various veterinary antibiotics.

2003

Reichl S., Müller-Goymann C.C.
Int J Pharm (2003) 250: 191-201
The use of a porcine organotypic cornea construct for permeation studies from formulations containing befunolol hydrochloride.

Reichl S., Müller-Goymann C.C.
BIOforum (2003) 10: 629-631
In Vitro Permeations-Modelle in der Pharmazie.

2001

Reichl S., Müller-Goymann C.C.
Ophthalmologe (2001) 98: 853-858
Development of an organotypical cornea construct as an in vitro model for permeation studies.

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2. Buchbeiträge

2008

Reichl S. and Becker U.
Cell culture models of the corneal epithelium and reconstructed cornea equivalents for in vitro drug absorption studies. In: Ehrhardt C & Kim KJ (Hrsg) Drug absorption studies – In situ, in vitro and in silico models, Springer, New York

3. Proceedings, Abstracts, Kongressbeiträge

2009

Reichl S.
AAPS Annual meeting 2009, Los Angeles
Biopolymer films based on human hair keratin as transferable cell substrates for ocular surface reconstruction

Verstraelen J., Reichl S.
DPhG Jahrestagung 2009, Jena
mRNA expression analysis of efflux transporters in corneal epithelial cell line (HCE-T) and excised cornea

Lusiana, Reichl S., Müller-Goymann C.C.
DPhG Jahrestagung 2009, Jena
The influence of nail penetrant enhancers on novel nail model made of human hair keratin

Hahne M., Reichl S.
DPhG Jahrestagung 2009, Jena
Influence of cultivation parameters on the barrier function of a serumfree cornea construct for drug absorption studies

Grobe G., Reichl S.
DPhG Jahrestagung 2009, Jena
Analyzing cell viability of immortalized human corneal keratocytes after Riboflavin/UVA-treatment

Reichl S.
107. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft 2009, Leipzig
Die künstliche Hornhaut – Ist ein Ende der Hornhautspende absehbar? – Update künstliches Stroma

Engelke M., Grobe G., Hahne M., Reichl S., Scholz H., Zorn-Kruppa M.
7th World congress on alternatives & animal use in the life sciences 2009, Rom
Prevalidation of a hemi-cornea model for corneal safety and permeability testing

Verstraelen J., Reichl S.
ARVO/ISOCB Meeting 2009, Ericeira, Portugal
mRNA expression analysis of efflux transporters in corneal epithelial cell line (HCE-T) and excised cornea

Lusiana, Reichl S., Müller-Goymann C.C.
2nd PharmSciFair 2009, Nizza
Keratin film from human hair as a novel model in replacing human nail plate for studying drug permeation

Grobe G., Reichl S.
Association of research in vision and ophthalmology Annual Meeting 2009, Fort Lauderdale, Florida
Analyzing cell viability of the stromal bioequivalent of a human cornea construct for drug absorption studies after riboflavin/UVA-treatment

Hahne M., Reichl S.
Association of research in vision and ophthalmology Annual Meeting 2009, Fort Lauderdale, Florida
Prevalidation of a Human Cornea Construct (HCC): Optimising barrier function and comparing with excised rabbit and porcine cornea

Meyer M., Dryja D., Reichl S., Meyer A., Winter R.
Association of research in vision and ophthalmology Annual Meeting 2009, Fort Lauderdale, Florida
Toxicity of bevacizumab to cultured human corneal endothelial cells in vitro

2008

Reichl S.
CRS German Chapter 2008, Braunschweig
Application of biopolymer films based on human hair keratin as a novel substrate for in vitro cell cultivation

Reichl S.
6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 2008, Barcelona
In-vitro evaluation of the permeation enhancing effect of reduced hair keratin on cultured corneal epithelium

Grobe G.M., Hahne M., Reichl S.
6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 2008, Barcelona
First steps towards the prevalidation of artifical human cornea models for studying trancorneal drug absorption in vitro and safety assessment of cosmetics and ophthalmologics

v Vietinghoff A., Reichl S.
6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 2008, Barcelona
Coculture of RPMI 2650 cells and human nasal fibroblasts to form a model construct of the human nasal mucosa for drug absorption studies

Meyer M., Dryja D., Reichl S., Brunotte I., Winter R.
57. Tagung der Vereinigung Norddeutscher Augenärzte 2008, Bremen
Analyse der Toxizität von Bevacizumab (Avastin) auf kultivierte Endothelzellen der Hornhaut

Hahne M., Reichl S.
106. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft 2008, Berlin
Prevalidation of an artificial human cornea construct for in vitro drug absorption studies: Optimisation of the corneal barrier by varying culture conditions

Grobe G.M., Reichl S.
106. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft 2008, Berlin
Influence of riboflavin and UVA-irradiation on cell viability and viscoelastic properties of the stromal bioequivalent of a human cornea construct for drug absorption studies

Meyer M., Dryja D., Reichl S., Brunotte I., Winter R.
106. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft 2008, Berlin
Toxicity of bevacizumab to cultured human corneal endothelial cells in vitro

Hahne M., Reichl S.
DPhG Jahrestagung 2008, Bonn
Optimizing barrier function of human cornea constructs by varying cultivation conditions

Wengst A., Reichl S.
DPhG Jahrestagung 2008, Bonn
RPMI 2650 cells as a model for studying drug absorption through human nasal mucosa

Grobe G.M., Reichl S.
DPhG Jahrestagung 2008, Bonn
Riboflavin/UVA-Treatment of the stromal layer of a human cornea construct

2007

Hahne M., Reichl S.
DOG Jahrestagung 2007, Berlin
Influence of dexpanthenol on regeneration of human corneal epithelial monolayers

v Vietinghoff A., Reichl S.
DPhG Jahrestagung 2007, Nürnberg
Barrier properties of the immortalized human nasal epithelial cell line RPMI 2650

Reichl S.
AAPS Annual Meeting 2007, San Diego
Investigations on a novel substrate coating based on human hair keratin - development and its use as growth substrate for in vitro cell culture methods

Reichl S.
AAPS Annual Meeting 2007, San Diego
Influence of reduced hair keratin on the permeability of sodium fluorescein across cultured corneal epithelium

2006

v Vietinghoff A., Reichl S.
6th International Conference and workshop on cell culture and In-Vitro models for drug absorption and delivery, Saarbrücken, 2006
Comparison of suitability of different supplements for improvement of viability of primary cultured human nasal epithelial cells.

Döhring S., Reichl S., Müller-Goymann C.C.
10th Congress of the International Society of Ocular Toxicology, Bonn-Königswinter, 2006
3D human cornea-constructs for cytotoxicity studies

Reichl S., Müller-Goymann C.C.
10th Congress of the International Society of Ocular Toxicology, Bonn-Königswinter, 2006
Organotypic 3D cell culture models of the cornea for in-vitro permeation studies

Reichl S.
DPhG Jahrestagung Joint-Meeting 2006, Marburg
Comparison of different cell culture models for studying transcorneal drug permeation.

Reichl S.
5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva, 27th – 30th March 2006
Comparison of the transepithelial permeability of the two commercially available reconstructed corneal epithelium models Epiocular® (Mattek) and RHCE (Skinethic)

Reichl S.
5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva, 27th – 30th March 2006
Keratin coated surfaces as growth substrate – a novel approach to stimulate cell proliferation in culture

v Vietinghoff A., Reichl S.
5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva, 27th – 30th March 2006
Influence of media supplements and surface treatments on the viability of human nasal epithelial cells in primary culture

Doehring S., Reichl S., Mueller-Goymann C.C.
5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva/Switzerland, 27th-30th March 2006
Qualification of human permeation models for cytotoxicity assays – A comparison of traditional monolayer studies with human cornea constructs (HCC)

2005

Aintablian A., Reichl S., Bednarz J.
54. Tagung der Vereinigung Norddeutscher Augenärzte (VNA), Hannover, 2005
Auf dem Weg zur künstlichen Hornhaut für Keratoplastik. Ein Zwischenbericht.

Döhring S., Reichl S., Müller-Goymann C.C.
9. GD-Jahrestagung, Wien, 2005, Eignung humaner organotypischer Permeations-modelle für Zytotoxizitätsuntersuchungen.

2004

Döhring S., Reichl S., Müller-Goymann C.C.
Proc. International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 15-18 March, 2004, p. 851-852, Comparison of the in vitro permeation of different ophthalmic drugs through a human cornea construct (HCC) and human donor corneas.

Reichl S., Müller-Goymann C.C.
5th International Conference and workshop on cell culture and In-Vitro models for drug absorption and delivery, Saarbrücken, 2004, Human cornea construct (HCC) for in vitro permeation studies.

Reichl S., Müller-Goymann C.C.
60. ZEBET Seminar: Entwicklung von menschlichen Hornhautmodellen für die Sicherheitstoxikologie, BfR Berlin, 2004, Entwicklung organotypischer cornealer Zellkulturmodelle für in vitro Permeationsuntersuchungen.

Friedrich I., Reichl S.
IPVS 18th Congress of the International Pig Veterinary Society, Hamburg, 2004, Study on solubility and handling of various original and generic veterinary antibiotics.

Meyer L., Reichl S.
Jahrestagung DPhG - Joint Meeting, Regensburg, 2004, Esterase activity of organotypic human cornea construct.

2003

Reichl S., Müller-Goymann C.C.
Doktorandentagung der DPhG, 2003, Düsseldorf, Ein humanes Cornea-Konstrukt für in vitro Permeationsuntersuchungen - Einfluss von Endothel und Stroma auf die Barriereeigenschaften des Konstruktes.

2002

Reichl S., Müller-Goymann C.C.
Proceed. 4th World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, ADRITELF/APGI/APV, Florence, 8-11. April, 2002, p. 951-952, Befunolol hydrochloride permeation through a porcine organotypical cornea construct.

Reichl S., Bednarz J., Müller-Goymann C.C.
Jahrestagung der DPhG, Berlin, Arch. Pharm. 335, Suppl. 1, 57 (2002), Evaluation of a human cornea equivalent as in vitro model for determination of drug permeability across the cornea.

2001

Reichl S., Müller-Goymann C.C.
Jahrestagung der DPhG, Halle/Saale, Arch. Pharm. 334, Suppl. 2, 73 (2001), Cultivation of a porcine organotypic cornea construct and its use for various in vitro permeation studies.

2000

Reichl S., Müller-Goymann C.C.
Proceed. 3rd World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Berlin, 3-6. April, 2000, p. 329-330, Isolation and culture of porcine corneal cells.

Reichl S., Müller-Goymann C.C.
Jahrestagung der Deutschen Pharmazeutischen Gesellschaft (DPhG) , Münster, Arch. Pharm. 333, Suppl. 2, 19 (2000), Reconstructed porcine cornea as an in vitro model for permeation studies.

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4. Dissertation

S. Reichl
Dissertation TU Braunschweig 2003
Entwicklung porciner und humaner organotypischer cornealer Zellkulturmodelle für in vitro Permeationsuntersuchungen

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