Forschung

Stand: 06.01.09

1. Originalarbeiten
2. Buchbeiträge und Übersichtsartikel
3. Tagungsbeiträge
4. Doktorarbeit

1. Originalarbeiten

2009

Jasch K., Barth N., Fehr S., Bunjes H., Augustin W., Scholl S.,
A microfluidic approach for a continuous crystallization of drug carrier nanoparticles,
Chem. Eng. Technol. 32 (2009) 1806-1814.

Kuntsche J., Koch M.H.J., Fahr A., Bunjes H.,
Supercooled smectic nanoparticles: Influence of the matrix composition and in vitro cytotoxicity,
Eur. J. Pharm. Sci. 38 (2009) 238-248.

Hornig S., Bunjes H., Heinze T.,
Preparation and characterization of nanoparticles based on dextran-drug conjugates,
J. Coll. Interf. Sci. 338 (2009) 5662.

Rosenblatt K.M., Bunjes H.,
Poly(vinyl alcohol) as emulsifier stabilizes solid triglyceride drug carrier nanoparticles in the α-modification,
Mol. Pharmaceutics 6 (2009) 105-120.

2008

Kuntsche J., Bunjes H., Fahr A., Pappinen S., Suhonen M., Rönkkö S., Urtti A.,
Interaction of lipid nanoparticles with human epidermis and an organotypic cell culture model,
Int. J. Pharm. 354 (2008) 180-195.

Lehtinen J., Hyvönen Z., Subrizi A., Bunjes H., Urtti A.,
Glycosaminoglycan-resistant and pH-sensitive lipid-coated DNA-complexes produced by detergent removal method,
J. Control. Rel. 131 (2008) 145-149.

2007

Wörle G., Drechsler M., Koch M.H.J., Siekmann B., Westesen K., Bunjes H.,
Influence of composition and preparation parameters on the properties of aqueous monoolein dispersions,
Int. J. Pharm. 329 (2007) 150-157.

Bunjes H., Steiniger F., Richter W.,Bunjes H., Steiniger F., Richter W.,
Visualizing the structure of triglyceride nanoparticles in different crystal modifications,
Langmuir 23 (2007) 4005-4011.

Rosenblatt K., Douroumis D., Bunjes H.,
Drug release from differently structured monoolein/ poloxamer nanodispersions studied with differential pulse polarography and ultrafiltration at low pressure,
J. Pharm. Sci. 96 (2007) 1565-1575.

Kuntsche J., Bunjes H.,
Influence of preparation conditions and heat treatment on the properties of supercooled smectic cholesteryl myristate nanoparticles,
Eur. J. Pharm. Biopharm. 67 (2007) 612- 620.

2006

Wörle G., Siekmann B., Koch M.H.J., Bunjes H.,
Transformation of vesicular into cubic nanoparticles by autoclaving of aqueous monoolein/poloxamer dispersions,
Eur. J. Pharm. Sci. 27 (2006) 44-53.

Wörle G., Siekmann B., Bunjes H.,
Effect of drug loading on the transformation of vesicular into cubic nanoparticles during heat treatment of aqueous monoolein/poloxamer dispersions,
Eur. J. Pharm. Biopharm. 63 (2006) 128-133.

Flaten G.E., Bunjes H. Luthmann K., Brandl M.,
Drug permeability across a phospholipid vesicle based barrier 2. Characterization of barrier structure, storage stability and stability towards pH changes,
Eur. J. Pharm. Sci. 28 (2006) 336-343.

2005

Rosenblatt K., Bunjes, H., Seeling A., Oelschläger H.,
Investigations on the thermal behavior of omeprazole and other sulfoxides,
Pharmazie 60 (2005) 503-507.

Kuntsche J., Koch M.H.J., Drechsler M., Bunjes H.,
Crystallization behavior of supercooled smectic cholesteryl myristate nanoparticles containing phospholipids as stabilizers,
Colloids Surfaces B: Biointerfaces 44 (2005) 25-35.

Bunjes H., Koch M.H.J.,
Saturated phospholipids promote crystallization but slow down polymorphic transitions in triglyceride nanoparticles,
J. Control. Rel. 107 (2005) 229-243.

2004

Jores K., Mehnert W., Drechsler M., Bunjes H., Johann C., Mäder K.,
Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy,
J. Control. Rel. 95 (2004) 217-227.

Kuntsche J., Westesen K., Drechsler M., Koch M.H.J., Bunjes H.,
Supercooled smectic nanoparticles – a potential novel carrier system for poorly water soluble drugs,
Pharm. Res. 21 (2004) 1836-1845.

2003

Bunjes H., Koch M.H.J., Westesen K.,
Influence of emulsifiers on the crystallization of solid lipid nanoparticles,
J. Pharm. Sci. 92 (2003) 1509-1520.

2002

Bunjes H., Koch M.H.J., Westesen K.,
Effects of surfactants on the crystallization and polymorphism of lipid nanoparticles,
Progr. Colloid Polym. Sci. 121 (2002) 7-10.

Siekmann B., Bunjes H., Koch M.H.J., Westesen K.,
Preparation and structural investigations of colloidal dispersions prepared from cubic monoglyceride-water phases, Int. J. Pharm. 244 (2002) 33- 43.

2001

Unruh T., Bunjes H., Westesen K., Koch M.H.J.,
Investigations on the melting behaviour of triglyceride nanoparticles,
Colloid Polym. Sci. 279 (2001) 398-403.

Bunjes H., Drechsler M., Koch M.H.J., Westesen K.,
Incorporation of the model drug ubidecarenone into solid lipid nanoparticles,
Pharm. Res. 18 (2001) 287-293.

Westesen K., Drechsler M, Bunjes H.,
Colloidal dispersions based on solid lipids,
in: Dickinson E., Miller R. (Hrg.), Food Colloids: Fundamentals of Formulation, Royal Society of Chemistry, Cambridge, 2001, 103-115.

2000

Bunjes H., Koch M.H.J., Westesen K.,
Effect of particle size on colloidal solid triglycerides,
Langmuir 16 (2000), 5234-5241.

1999

Meyer H.W., Bunjes H., Ulrich A.S.,
Morphological transitions of brain sphingomyelin are determined by the hydration protocol: ripples re-arrange in plane, and sponge-like networks disintegrate into small vesicles.
Chem. Phys. Lipids 99 (1999) 111-123.

Oelschläger H., Seeling A., Seeling B., Westesen K., Bunjes H.,
Selektive Oxidation von 5-Methoxy- 2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylthio]-1-H-benzimidazol zu RS-5-Methoxy-2-[[(3,5- dimethyl-4-methoxy-2-pyridyl)methyl]sulfinyl]-1-H-benzimidazol (Omeprazol).
Pharmazie 54 (1999) 734-737.

Unruh T., Bunjes H., Westesen K., Koch M.H.J.,
Observation of size-dependent melting in lipid nanoparticles,
J. Phys. Chem. B 103 (1999) 10373-10377.

1997

Westesen K., Bunjes H., Koch M.H.J.,
Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential,
J. Control. Rel. 48 (1997) 223-236.

1996

Bunjes H., Westesen K., Koch M.H. J.,
Crystallization tendency and polymorphic transitions in triglyceride nanoparticles,
Int. J. Pharm. 129 (1996) 159-173.

1995

Westesen K., Bunjes H.,
Do nanoparticles prepared from lipids solid at room temperature always possess a solid lipid matrix?
Int. J. Pharm. 115 (1995) 129-131.

Westesen K., Bunjes H., Koch M.H.J.,
Phase behavior of tyloxapol/Triton X100/water mixtures,
J. Pharm. Sci. 84 (1995) 544-550.

2. Buchbeiträge und Übersichtsartikel

2007

Bunjes H.,
Multiple Emulsionen in der Pharmazie, in: Muschiolik G., Bunjes H. (Hrg.) Multiple Emulsionen – Herstellung und Eigenschaften,
Behr’s Verlag, Hamburg, 2007, 207-241.

Bunjes H., Kuntsche J.,
Supercooled Smectic Nanoparticles, in: Thassu D., Deleers M., Pathak Y. (Hrsg.) Nanoparticulate Drug Delivery Systems,
Informa Health Care, New York, 2007, 129-140.

Bunjes H., Unruh T.,
Characterization of lipid nanoparticles by differential scanning calorimetry, XRay and neutron scattering;
Adv. Drug Deliv. Rev. 59 (2007) 379-402.

2006

Bunjes H., Siekmann B.,
Manufacture, Characterization and applications of solid lipid nanoparticles as drug delivery systems, in: Microencapsulation, 2. Auflage, Benita S. (Hrg.)
Marcel Dekker, New York, 2006, 213-268.

2005

Bunjes H., Rades T.,
Thermotropic Liquid Crystalline Drugs,
J. Pharm. Pharmcol. 57 (2005) 807- 810.

Bunjes H.,
Characterization of solid lipid nano- and microparticles, in: Lipospheres in Drug Targets and Delivery, Nastruzzi C. (Hrg.),
CRC Press, Boca Raton, 2005, 41-66.

2001

Bunjes H., Westesen K.,
Influences of colloidal state on physical properties of solid fats, in: Garti N., Sato K. (Hrg.), Crystallization processes in fats and lipid systems,
Marcel Dekker, New York, 2001, 457-483.

Westesen K., Bunjes H., Hammer G., Siekmann B.
Novel colloidal drug delivery systems,
PDA Journal of Pharmaceutical Science and Technology 55 (2001) 240-247.

1998

Bunjes H., Siekmann B., Westesen K.,
Emulsions of supercooled melts - a novel drug delivery system, in: Submicron Emulsions in Drug Targeting and Delivery, Benita S. (Hrg.)
Harwood Academic Publishers, Chur, 1998, 175-218.

3. Tagungsbeiträge

2009

Dawoud M., Fahr A., Bunjes H.,
Poster, DPhG Jahrestagung, Jena, September 29th-October 1st, 2009, (Abstract # C23)
Comparison of drug transfer from lipid nanoparticles into different types of acceptor particles.

Fehr S., Bunjes H.,
Vortrag, DPhG Jahrestagung, Jena, September 29th-October 1st, 2009, (Abstract # K12)
Preparation of nanoemulsions and solid lipid nanoparticles by small-volume extrusion.

Horst, J.C., Bunjes H.
Poster, DPhG Jahrestagung, Jena, September 29th-October 1st, 2009, (Abstract # C30)
Isotonization studies on dispersed cubic phases.

Mengersen, F., Bunjes H.
Poster, DPhG Jahrestagung, Jena, September 29th-October 1st, 2009, (Abstract # C33)
Surface Modification of Preformed Supercooled Smectic Nanoparticles with MPEG 2000-DSPE.

Petersen S., Fischer D., Fahr A, Bunjes H.,
Poster, DPhG Jahrestagung, Jena, September 29th-October 1st, 2009, (Abstract # C21)
The physical state of lipid nanoparticles affects the in vitro cell viability.

Strasdat B., Bunjes H.
Poster, DPhG Jahrestagung, Jena, September 29th-October 1st, 2009, (Abstract # C37)
A Novel Approach to Study the Release of Lipophilic Drugs from Colloidal Carrier Systems.

Woehl-Bruhn S., Schwoerer A., Harling S., Bertz A., Daniels R., Menzel H., Bunjes H.
Poster, DPhG Jahrestagung, Jena, September 29th-October 1st, 2009, (Abstract # C36)
Hydrogel Microparticles as Drug Delivery Systems for the Controlled Release of Biomacromolecules.

Petersen S., Fischer D., Fahr A., Bunjes H.
The physical state of lipid nanoparticles affects their in vitro cell viability.
Poster, 36th Annual Meeting & Exposition of the Controlled Release Society, Kopenhagen, Dänemark, 18.-22. Juli 2009 (Transactions #972).

Bunjes H., Koch M.H.J., Westesen K.
Partikelgrößenabhängigkeit des thermischen Verhaltens von Triglycerid-Nanopartikeln.
Poster, 248. PTB-Seminar in Braunschweig, 18./19. Mai 2009 (PTB-Bericht PTB-CP-4).

Mengersen F., Bunjes H.
Surface modification of supercooled smectic cholesteryl myristate nanoparticles.
Poster, Symposium Phospholipids in Pharmaceutical Research, 11./12. Mai 2009 (Abstractband).

Bunjes H.
Delivering poorly soluble drugs using solid lipid nanosuspensions.
APS Poorly Soluble Drugs Conference, Aston University, Birmingham, Großbritannien, 15./16. April 2009.

Dawoud M., Fahr A., Bunjes H.
Vortrag, Controlled Release Society German Chapter Annual Meeting 2009, Halle/Saale, March 19th-20th, 2009, (Abstractband S. 26)
Transfer of a lipophilic drug model from lipid nanoparticles to liposomes studied with two different methods.

Mengersen F., Bunjes H.
Poster, Controlled Release Society German Chapter Annual Meeting 2009, Halle/Saale, March 19th-20th, 2009, (Abstractband S. 56)
Surface Modification of Supercooled Smectic Cholesteryl Myristate Nanoparticles.

Meyer L., Bunjes H.
Poster, Controlled Release Society German Chapter Annual Meeting 2009, Halle/Saale, March 19th-20th, 2009, (Abstractband S. 59)
Process optimization in drug release studies on colloidal drug carriers.

Petersen S., Fischer D., Fahr A., Bunjes H.
Vortrag, Controlled Release Society German Chapter Annual Meeting 2009, Halle/Saale, March 19th-20th, 2009, (Abstractband S. 29)
Effect of lipid nanoparticles on in vitro cell viability.

Presselt K., Bunjes H., Nowak G.
Poster, Controlled Release Society German Chapter Annual Meeting 2009, Halle/Saale, March 19th-20th, 2009, (Abstractband S. 67)
Treatment of experimentally induced colitis with silicone oil emulsions.

Jasch K., Augustin W., Fehr S., Bunjes H., Finke J.H., Müller-Goymann C., Scholl S.
Kontinuierliche Kristallisation fester Lipidnanopartikel in Mikrostrukturen.
Vortrag, ProcessNet-Fachausschüsse Kristallisation und Fluidverfahrenstechnik 2009, Dortmund, März 2009.

2008

Presselt K., Nowak G., Bunjes H.,
Effect of aqueous phase viscosity on the size of silicone oil droplets and lipid nanoparticles.
Vortrag, DPhG-Jahrestagung 2008, Bonn, 8.-11. Oktober 2008 (Abstract # K43). Meyer L., Bunjes H., Evaluation of different membranes as filters in release studies on colloidal drug carriers, Poster, DPhG-Jahrestagung 2008, Bonn, 8.-11. Oktober 2008 (Abstract # B83).

Bode K., Bunjes H., Fehr S., Augustin W., Scholl S.,
A microfluidic approach to study cooling rate dependent crystallisation properties of triglyceride-based drug carrier nanoparticles.
Poster, British Association for Crystal Growth - Conference 2008, Loughborough, Großbritannien, 7.- 9. September 2008 (Abstractband S. 69).

Presselt K., Frant M., Bunjes H., Nowak G.,
Untersuchungen zur Oberflächenspannung und zum Benetzungsverhalten von Siliconölemulsionen.
Vortrag, 14. Heiligenstädter Kolloquium: Technische Systeme für die Lebenswissenschaften, Heilbad Heiligenstadt, 22.- 24.September 2008.

Bunjes H.,
Drug delivery by nano-carriers.
Invited CRS lecture, 2nd Midnight Sun Meeting on Drug Transport & Delivery, Tromsø, Norwegen, 25.- 27. Juni 2008 (Abstract # 20).

Rosenblatt K. M., Bunjes H.,
Drug loading studies on lipid nanoparticles.
Poster, 2nd Midnight Sun Meeting on Drug Transport & Delivery, Tromsø, Norwegen, 25.- 27. Juni 2008 (Abstract # 46).

Petersen S., Arendt J.M., Fahr A., Bunjes H.,
Transfer of fluorescent dyes from lipid nanoparticles to O/W emulsions.
Poster, 2nd Midnight Sun Meeting on Drug Transport & Delivery, Tromsø, Norwegen, 25.- 27. Juni 2008 (Abstract # 47).

Petersen S., Arendt J.M., Fahr A., Bunjes H.,
Investigations on the transfer of fluorescent dyes from lipid nanoparticles to O/W emulsions using flow cytometry.
Vortrag, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spanien, 7.-10. April 2008

Rosenblatt K. M., Bunjes H.,
A screening approach to determine the solubilization capacity of lipid nanoparticles for poorly water soluble drugs.
Poster, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spanien, 7.-10. April 2008 (Posterabstract #126).

Eppler A., Weigandt M., Rübe A., Bunjes H.,
Analysis of stress conditions in protein formulation development: Influence of different filling volumes and shaking intensities in a 6 ml vial.
Poster, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spanien, 7.-10. April 2008 (Posterabstract #91).

Petersen S., Arendt J.M., Fahr A., Bunjes H.,
Dye transfer from lipid nanoparticles to lipid acceptor compartments.
Vortrag, Controlled Release Society German Chapter Annual Meeting 2008, Braunschweig, 4.-5. März 2008 (Abstractband S. 20).

Dawoud M., Fahr A., Kuntsche J., Bunjes H.,
Investigations on the transfer of porphyrin from o/w emulsion droplets to liposomes with two different methods.
Poster, Controlled Release Society German Chapter Annual Meeting 2008, Braunschweig, 4.-5. März 2008 (Abstractband S. 28).

Eichelroth K., Nowak G., Bunjes H.,
Influence of different parameters on the antibacterial activity of silicone oil emulsions.
Poster, Controlled Release Society German Chapter Annual Meeting 2008, Braunschweig, 4.-5. März 2008 (Abstractband S. 31).

Eppler A., Weigandt M., Rübe A., Bunjes H.,
Stress conditions in protein formulation development: A comparison of two antibody solutions in different containers during shaking.
Poster, Controlled Release Society German Chapter Annual Meeting 2008, Braunschweig, 4.-5. März 2008 (Abstractband S. 32).

2007

Petersen S., Arendt J.M., Bunjes H.,
Investigations on the transfer of the dye Nile red from lipid nanoparticles to o/w emulsions using flow cytometry.
Poster, Controlled Release Society German Chapter Annual Meeting 2007, Freiburg, Germany, March 22/23, 2007.
Abstract: Abstractband S. 55.

Eichelroth K., Nowak G., Bunjes H.,
Evaluation of the antimicrobial activity of silicone oil emulsions.
Poster, Controlled Release Society German Chapter Annual Meeting 2007, Freiburg, Germany, March 22/23, 2007.
Abstract: Abstractband S. 37

Bunjes H.,
Lipid nanoparticles and their interactions with drugs (invited paper),
CRS German Chapter Annual Meeting, Freiburg/Brsg., März 22-23, 2007.
Abstract: Abstractband S. 9.

Bunjes H.,
Einfluss von Emulgatoren auf das Kristallisationsverhalten von Triglycerid-Nanopartikeln,
Vortrag, 17. Ulm-Freiberger Kalorimetrietage, Freiberg/Sa., März 28-30, 2007.
Abstract: Abstractband S. 22.

Rosenblatt K., Bunjes H.,
Poly(vinyl alcohol) stabilizes the alpha-modification in triglyceride nanoparticles.
Poster, 43rd Meeting of the Colloid Society, Mainz, Germany, Oktober 8-10, 2007.
Abstract: Abstractband # P22.

Petersen S., Arendt J.M., Fahr A., Bunjes H.,
Flow cytometric investigations on the transfer of fluorescent dyes from lipid nanoparticles to o/w emulsions.
Poster, 43rd Meeting of the Colloid Society, Mainz, Germany, Oktober 8-10, 2007.
Abstract: Abstractband # P52.

2006

Eichelroth K., Nowak G., Bunjes H.,
Preparation and characterization of silicon oil emulsions for pharmaceutical application.
Poster, Controlled Release Society German Chapter Annual Meeting 2006, Jena, Februar 23/24, 2006.
Abstract: Abstractband S. 26.

Petersen S., Bunjes H.,
Stability of different lipid nanoparticle formulations in various media.
Poster, Controlled Release Society German Chapter Annual Meeting 2006, Jena, Februar 23/24, 2006.
Abstract: Abstractband S. 37.

Bunjes H., Steiniger, F.,
Visualizing the structure of tristearin nanoparticles in different crystal modifications.
Poster, 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Genf, Schweiz, März 27-30, 2006.
Abstract: Proc. 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Unruh T., Smuda C., Gemmecker G., Bunjes H.,
Molecular dynamics in pharmaceutical drug delivery systems – the potential of QENS and first experimental results.
8th Quasi-Elastic Neutron Scattering Conference, Bloomington, IN, USA, June 14-17 2006
Veröffentlicht in: Sokol P.E. (Hrg.) Proc. Int. Conf. Quasi Eleastic Neutron Scattering 2006, Materials Science Society, Warrendale, USA, 2007, 137-145.

Bunjes H., Kuntsche J., Drechsler, M., Koch, M.H.J.,
Supercooled smectic nanoparticles – development and characterization of a novel drug delivery system.
“Invited Paper”, Particles 2006, Orlando, USA, Mai 13-16, 2006.
Abstract: Abstractband S. 43.

Rosenblatt K., Bunjes H.,
Comparison of drug release from trimyristin nanosuspensions and nanoemulsions with differential puls polarography.
Poster, 33rd Annual Meeting & Exposition of the Controlled Release Society, Wien, Österreich, Juli 22-26, 2006.
Abstract: Transactions # 323.

Kuntsche J., Bunjes, H.,
Investigations on the stability of supercooled smectic nanoparticles upon autoclaving and heat treatment.
Poster, 33rd Annual Meeting & Exposition of the Controlled Release Society, Wien, Österreich, Juli 22-26, 2006.
Abstract: Transactions # 357.

Lehtinen J., Subrizi A., Bunjes H., Urtti A.,
Protection of cationic gene complexes against glycosaminoglycans by anionic lipid coating.
Poster, 33rd Annual Meeting & Exposition of the Controlled Release Society, Wien, Österreich, Juli 22-26, 2006.
Abstract: Transactions # 724.

Kuntsche J., Bunjes H., Urtti A.,
Interaction of Different Kinds of Lipid Nanoparticles with Human Skin and an Organotypic Cell Culture Model.
Poster, 33rd Annual Meeting & Exposition of the Controlled Release Society, Wien, Österreich, Juli 22-26, 2006.
Abstract: Transactions # 1081.

Bunjes H., Kuntsche J., Wörle G.,
Investigation of dynamic processes in lipid-based nanoparticulate drug carrier systems with small and wide angle X-ray diffraction.
Vortrag, 23rd European Crystallographic Meeting, ECM23, Leuven, Belgien, August 6-11, 2006.
Abstract: Acta Cryst. (2006). A62, s99A.

2005

Bunjes H.,
Morphology and internal structure of solid triglyceride nanoparticles can be modified by specific combination of matrix lipid, stabilizer and thermal treatment”,
Controlled Release Society German Chapter Annual Meeting 2005, Marburg, März 14/15, 2005.
Abstract: Abstractband S. 16.

Rosenblatt K., Douroumis D., Bunjes H.,
Drug release studies on colloidal lipid dispersions with different ultrastructure using differential pulse polarography and ultrafiltration at low pressure,
Vortrag, Controlled Release Society German Chapter Annual Meeting 2005, Marburg, März 14/15 2005.
Abstract: Abstractband S. 8.

Bunjes H.,
Modification of the crystallization behavior of triglyceride nanoparticles by the type of stabilizing phospholipid.
Vortrag, 42. Hauptversammlung der Kolloidgesellschaft, Aachen, September 26-28, 2005.
Abstract: Abstractband L53B.

Rosenblatt K., Douroumis D., Bunjes H.,
Comparison of two methods for the study of drug release from colloidal lipid dispersions.
Poster, 42. Hauptversammlung der Kolloidgesellschaft, Aachen, September 26-28, 2005.
Abstract: Abstractband P 39.

2004

Bunjes H.,
Kolloidale Lipidpartikel als Arzneistoffträgersysteme.
„Invited paper“. GDL-Symposium “Verkapseln, Mikroverkapseln, Coaten“, Jena, Februar 12/13, 2004.

Wörle G., Siekmann B., Bunjes H.,
Transformation of vesicular into cubic particles upon autoclaving,
Vortrag, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nürnberg, März 15-18, 2004.
Abstract: Proc. International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 15-18 March 2004, 845-846.

Kuntsche J., Westesen K., Drechsler M., Bunjes H.,
Crystallization behavior of supercooled smectic nanoparticles: Particularities of phospholipid based systems.
Poster, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nürnberg, März 15-18, 2004.
Abstract: Proc. International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 15-18 March 2004, 469-470.

Jores K., Mehnert W., Bunjes H., Drechsler M., Mäder K.,
From solid lipid nanoparticles (SLN) to nanospoons. Visions and reality of colloidal lipid dispersions.
Vortrag, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nürnberg, März 15-18, 2004.
Abstract: Proc. International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 15-18 March 2004, 439-440.

Ruponen M., Bunjes, H., Lehtinen J., Tammi M., Honkakoski P., Urtti A.,
Mechanisms of DNA delivery with liposomal and polymeric systems.
Vortrag, The Midnight Sun Meeting on Drug Transport and Drug Delivery, Tromsø, Norwegen, Juli 1-3, 2004.
Abstract: Abstractbuch S. 21

Bunjes H.,
Saturated phospholipids promote crystallization but slow down polymorphism in lipid nanoparticles.
Poster, DPhG Jahrestagung – Joint Meeting 2004, Regensburg, Oktober 6-9, 2004.
Abstract: Abstractbuch S. 152

Rosenblatt K., Douroumis D., Bunjes H.,
Drug release studies on monoolein/poloxamer dispersions using differential pulse polarography.
Poster, DPhG Jahrestagung – Joint Meeting 2004, Regensburg, Oktober 6-9, 2004.
Abstract: Abstractbuch S. 161

Wörle G., Siekmann B., Bunjes H., Influence of autoclaving on the ultrastructure of aqueous monoolein/poloxamer dispersions. Poster, EUFEPS 2004, Brüssel, Belgien, Oktober 17-20, 2004. Abstract: Eur. J. Pharm. Sci.23S (2004) S45

Bunjes H.,
Untersuchungen an unterkühlt-smektischen Cholesterolester-Nanopartikeln.
Vortrag, 1. Treffen der Pharmazeutischen Technologie Mitteldeutschlands, Institut für Pharmazeutische Technologie und Biopharmazie, Universität Halle, 22.10.2004.

2003

Bunjes H.,
Physicochemical Aspects of Lipid Nanoparticles,
“Invited paper”, The 14th Annual Symposium of Physical Pharmacy, Kuopio, Finnland, Januar 22/23, 2003.
Abstract: Abstractband S. 7-9.

Bunjes H., Kuntsche J., Hammer G., Drechsler M., Koch M.H.J., Westesen K.,
Supercooled smectic nanoparticles – a novel carrier system for poorly water soluble drugs.
30th Annual Meeting of the Controlled Release Society, Glasgow, Großbritannien, Juli 19-23, 2003.
Abstract: Proceed. Int. Symp. Control. Bioact. Mater. 30 (2003) #56.

Kuntsche J., Westesen K., Bunjes H.,
Supercooled smectic nanoparticles – Influence of the Matrix Composition on the Phase Behavior.
Poster, 30th Annual Meeting of the Controlled Release Society, Glasgow, Großbritannien, Juli 19-23, 2003.
Abstract: Proceed. Int. Symp. Control. Bioact. Mater. 30 (2003) #182.

Kuntsche J., Westesen K., Bunjes H.,
Supercooled smectic nanoparticles – Influence of the stabilizer system on physicochemical properties.
Poster, 30th Annual Meeting of the Controlled Release Society, Glasgow, Großbritannien, Juli 19-23, 2003.
Abstract: Proceed. Int. Symp. Control. Bioact. Mater. 30 (2003) #199.

Jores K., Mehnert W., Bunjes H., Drechsler M., Mäder K.,
From solid lipid nanoparticles (SLN) to nanospoons. Visions and reality of colloidal lipid dispersions.
Poster, 30th Annual Meeting of the Controlled Release Society, Glasgow, Großbritannien, Juli 19-23, 2003.
Abstract: Proceed. Int. Symp. Control. Bioact. Mater. 30 (2003) #181.

Kuntsche J., Westesen K., Bunjes H.,
Crystallization behavior of cholesterol ester nanoparticles in dependence on composition.
Poster, 42. Hauptversammlung der Kolloidgesellschaft/Bayreuth Polymer Symposium, Bayreuth, September 28-30, 2003
Abstract: Abstractband PI 16.

Kuntsche J., Westesen K., Bunjes H.,
Investigations on physicochemical properties of cholesteryl myristate nanoparticles
Vortrag, DPhG-Jahrestagung 2003, Würzburg, Oktober 8-12, 2003.
Abstract: Abstractband S. 55.

2002

Bunjes H., Koch M.H.J.,
Induction of triglyceride crystallization in lipid nanoparticles by interaction with surfactants.
Poster, GRC „Drug Carriers in Medicine and Biology“, Ventura, USA, Februar 24 – März 1, 2002.

Bunjes H., Koch M.H.J.,
Induction of triglyceride crystallization in lipid nanoparticles by interaction with surfactants.
Poster, 6. Nachwuchstage der Kolloid- und Grenzflächenforschung, Berlin, März 21 - 22, 2002.
Abstract: Book of Abstracts # 36

Wörle G., Siekmann B., Bunjes H.,
Einfluß von Herstellungsparametern auf kolloidale Dispersionen des Systems Monoolein/Poloxamer/Wasser,
Poster, 6. Nachwuchstage der Kolloid- und Grenzflächenforschung, Berlin, März 21-22, 2002.
Abstract: Book of Abstracts # 35

Bunjes H., Westesen K.,
Stabilizers may decrease the amount of supercooling in lipid nanoparticle dispersions.
Vortrag, 4th World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, Florenz, Italien, April 8-11, 2002.
Abstract: Proc. 4th World Meeting ADRTELF/APGI/APV, Florence, 8/11 April 2002, 671-672.

Bunjes H., Koch M.H.J., Westesen K.,
Crystallization of lipid nanoparticles – the influence of stabilizers.
Vortrag (“invited paper”), Particles 2002, Orlando, USA, April 20-23, 2002.
Abstract: Book of Abstracts p. 51

Bunjes H., Koch M.H.J.,
Structure formation in the interface of supercooled triglyceride nanoparticles prior to crystallization.
Vortrag, Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Berlin, Oktober 9-12, 2002.
Abstract: Arch. Pharm. Pharm. Med. Chem. 335, Suppl. 1 (2002) 56.

Wörle G., Drechsler M., Koch M.H.J., Siekmann B., Westesen K., Bunjes H.,
Influence of composition and preparation parameters on the properties of aqueous monoolein dispersions.
Vortrag, Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Berlin, Oktober 9-12, 2002.
Abstract: Arch. Pharm. Pharm. Med. Chem. 335, Suppl. 1 (2002) 57.

Rosenblatt K., Bunjes H., Seeling A., Oelschläger H.,
Investigations on the melting behavior of omeprazole.
Poster, Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Berlin, Oktober 9-12
Abstract: Arch. Pharm. Pharm. Med. Chem. 335, Suppl. 1 (2002) 96.

Bunjes H., Koch M.H.J.,
Influence of surfactants on the crystallization of triglyceride nanoparticles.
Poster, EUFEPS 2002 – 7th European Congress of Pharmaceutical Sciences, Stockholm, Schweden, Oktober 21-23, 2002.
Abstract: Eur. J. Pharm. Sci. 17S (2002) S95.

Wörle G., Siekmann B., Bunjes H.,
Influence of preparation parameters on monoolein/poloxamer/water-dispersions.
Poster, EUFEPS 2002 – 7th European Congress of Pharmaceutical Sciences, Stockholm, Schweden, Oktober 21-23, 2002.
Abstract: Eur. J. Pharm. Sci. 17S (2002) S136.

2001

Bunjes H., Koch M.H.J., Westesen K.,
Stabilizer effects on crystallization and polymorphism of solid lipid nanoparticles,
Vortrag, 40. Hauptversammlung der Kolloidgesellschaft, Potsdam, September 24-26, 2001.
Abstract: Book of Abstracts, 52.

Bunjes H., Koch M.H.J., Westesen K.,
Influence of stabilizers on the crystallization of lipid nanoparticles,
Vortrag, Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Halle/Saale, Oktober 10-13, 2001.
Abstract: Arch. Pharm. Pharm. Med. Chem. 334, Suppl. 2 (2001) 25.

2000

Westesen K., Bunjes H., Hammer G, Siekmann B.,
Novel colloidal drug delivery systems, Annual Meeting of the PDA, Basel, Schweiz, Februar 2000.
Veröffentlicht in: PDA Journal of Pharmaceutical Science and Technology 55 (2001) 240-247.

Bunjes H., Drechsler M., Koch M.H.J., Westesen K.,
Interactions of the model drug ubidecarenone (Q10) with triglyceride nanoparticles.
Poster, GRC „Drug Carriers in Medicine and Biology“, Ventura, USA, Februar 20-25, 2000.

Westesen K., Drechsler M., Bunjes H.,
Colloidal Dispersions Based on Solid Lipids, Food Colloids 2000: Fundamentals of Formulation, Potsdam, April 2-5, 2000.
Veröffentlicht in: Dickinson E., Miller R. (Eds.),
Food Colloids: Fundamentals of Formulation, Royal Society of Chemistry, Cambridge, 2001, 103-115.

Bunjes H., Drechsler M., Koch M.H.J., Westesen K.,
Phase separation within solid lipid nanoparticles loaded with high amounts of ubidecarenone (Q10),
Poster, The 27th International Symposium on Controlled Release of Bioactive Materials, Paris, Frankreich, Juli 9-13, 2000.
Abstract: Proceed. Int. Symp. Control. Rel. Bioact. Mater., 27 (2000) # 8127.

Westesen K., Bunjes H., Drechsler M., Hammer G., Mehlem J., Schaal G., Unruh T.,
Colloidal lipidbased carrier systems and drug dispersions,
Poster, Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Münster, Oktober 4-7, 2000.
Abstract: Arch. Pharm. Pharm. Med. Chem. 333, Suppl. 2 (2000) 35.

Westesen K., Bunjes H., Drechsler M., Lauf U., Unruh T., Wörle G.,
Surfactant-based formulations,
Poster, Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Münster, Oktober 4-7, 2000.
Abstract: Arch. Pharm. Pharm. Med. Chem. 333, Suppl. 2 (2000) 35.

1999

Drechsler M., Bunjes H., Hammer G., Westesen K.,
Cryo-TEM and freeze-fracture-TEM of ubidecarenone (coenzyme Q10) containing aqueous colloidal dispersions.
Poster, 29. Tagung der Deutschen Gesellschaft für Elektronenmikroskopie, Dortmund, September 5-10, 1999.
Abstract: Eur. J. Cell Biol. S50 (Vol. 78) 81.

Bunjes H., Koch M.H.J., Westesen K.,
Influence of stabilizers on the polymorphism of colloidal triglycerides.
Vortrag, 39. Hauptversammlung der Kolloidgesellschaft, Würzburg, September 27-30, 1999.
Abstract: Book of Abstracts, 69.

Bunjes H., Drechsler M., Koch M.H.J., Westesen K.,
Vortrag, 39. Hauptversammlung der Kolloidgesellschaft, Würzburg, September 27-30, 1999.
Abstract: Book of Abstracts, 70.

Unruh T., Bunjes H., Westesen K., Koch M.H.J.,
Investigations on the melting behavior of triglyceride nanoparticles.
39. Hauptversammlung der Kolloidgesellschaft, Würzburg, September 27-30, 1999.
Abstract: Book of Abstracts, 68.

Bunjes H., Koch M.H.J., Westesen K.,
Influence of stabilizers on the polymorphism of triglyceride nanoparticles.
Poster, Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Frankfurt/Main, Oktober 6-9, 1999.
Abstract: Arch. Pharm. Pharm. Med. Chem. 332, Suppl. 2 (1999) 7.

1998

Unruh T., Bunjes H., Westesen K., Koch M.H.J.,
Investigations on the melting behaviour of solid lipid nanoparticles.
Bunsentagung 1998, Münster, Mai 21-23, 1998.
Abstract: Book of Abstracts, B114.

Bunjes H., Drechsler M., Westesen K.,
Localization of ubidecarenone in triglyceride nanoparticle dispersions.
Vortrag, Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Tübingen, November 6- 8, 1998.
Abstract: Arch. Pharm. Pharm. Med. Chem. 331, Suppl. 2 (1998) 53.

Unruh T., Bunjes H., Westesen K., Koch M.H.J.,
Investigations on a fundamental melting effect of solid lipid nanoparticles and its potential for drug delivery systems.
Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Tübingen, November 6-8, 1998.
Abstract: Arch. Pharm. Pharm. Med. Chem. 331, Suppl. 2 (1998) 53.

1997

Bunjes H., Westesen K., Koch M.H.J.,
Verhalten kleiner Lipidnanopartikel.
Vortrag, 9. Frühjahrstagung der Deutschen Pharmazeutischen Gesellschaft e.V. für den wissenschaftlichen Nachwuchs, Würzburg, März 13- 16, 1997.
Abstract: Abstractband, V 23.

Siekmann B., Bunjes H., Koch M.H.J., Westesen K.,
An X-ray study on colloidal monoglyceridewater dispersions.
Poster, Colloidal Drug Carriers - 3rd Expert Meeting, Berlin, Mai 29-31, 1997.
Abstract: in: Müller R.H., Benita S., Böhm B. (Hrg.)
Emulsions and Nanosuspensions for the Formulation of Poorly Water Soluble Drugs, Medpharm Scientific Publishers, Stuttgart 1998, 318- 319.

Bunjes H., Westesen K., Koch M.H.J.,
Multiple melting behavior of lipid nanoparticles.
Poster, Colloidal Drug Carriers - 3rd Expert Meeting, Berlin, Mai 29-31, 1997.
Abstract: in: Müller R.H., Benita S., Böhm B. (Hrg.)
Emulsions and Nanosuspensions for the Formulation of Poorly Water Soluble Drugs, Medpharm Scientific Publishers, Stuttgart 1998, 320- 321.

Westesen K., Bunjes H.,
Effect of the physical state of lipid nanoparticles on incorporated drugs - an NMR study.
Poster, Colloidal Drug Carriers - 3rd Expert Meeting, Berlin, Mai 29-31, 1997.
Abstract: in: Müller R.H., Benita S., Böhm B. (Hrg.)
Emulsions and Nanosuspensions for the Formulation of Poorly Water Soluble Drugs, Medpharm Scientific Publishers, Stuttgart 1998, 322-324.

Siekmann B., Bunjes H., Koch M.H.J., Carlson T., Westesen K.,
Synchrotron X-ray investigation of the structure of colloidal dispersions of liquid crystalline monoolein-water-phases.
Poster, The 24th International Symposium on Controlled Release of Bioactive Materials, Stockholm, Schweden, Juni 15-19, 1997.
Abstract: Proceed. Int. Symp. Control. Bioact. Mater. 24 (1997) 943-944.

Bunjes H., Westesen K., Koch M.H.J.,
Effect of the particle size on the phase transitions of solid lipid nanoparticles.
Poster, The 24th International Symposium on Controlled Release of Bioactive Materials, Stockholm, Schweden, Juni 15- 19, 1997.
Abstract: Proceed. Int. Symp. Control. Bioact. Mater. 24 (1997) 945-946.

Bunjes H., Westesen K., Koch M.H.J.,
Size effects in triglyceride nanoparticles.
Poster, Kolloidtagung 1997, Essen, September 29 – Oktober 1, 1997.
Abstract: Book of Abstracts, 145-146.

1996

Bunjes H., Westesen K., Koch, M.H.J.,
Incorporation of a model drug into lipid nanoparticle dispersions.
Vortrag, 42. Jahrestagung der APV, Mainz, Germany, März 7-9, 1996.
Abstract: Eur. J. Pharm. Biopharm. 42 (Suppl.) 1996, 33S.

Bunjes H., Westesen K., Koch M.H.J.,
Crystallization of triglyceride nanoparticles.
Vortrag, 11th International Symposium on Surfactants in Solution in Jerusalem, Israel, Juni 9-13, 1996.
Abstract: Book of Abstracts, 267.

Bunjes H., Westesen K., Koch M.H.J.,
Effect of particle size on properties of solid lipid nanoparticles.
Poster, 11th International Symposium on Surfactants in Solution in Jerusalem, Israel, Juni 9-13, 1996.
Abstract: Book of Abstracts, 267.

1995

Bunjes H., Westesen K., Koch M.H.J.,
Complex fats as matrix constituents in lipid nanoparticles.
Poster, 1st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, Budapest, Ungarn, Mai 9-11, 1995.
Abstract: Proc. 1st World Meeting APGI/APV, Budapest, 9/11 May 1995, 497-498.

Bunjes H., Westesen K., Koch M.H.J.,
Recrystallization tendency and polymorphic transitions in triglyceride nanoparticles.
1st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, Budapest, Ungarn, Mai 9-11, 1995.
Abstract: Proc. 1st World Meeting APGI/APV, Budapest, 9/11 May 1995, 497-498.

Bunjes H., Westesen K., Koch M.H.J.,
Influence of drug-load on solid lipid nanoparticles.
Poster, Colloidal Drug Carriers, 1st Expert Meeting, Berlin, Juni 15-17, 1995.

Westesen K., Bunjes H., Koch M.H.J.,
Do nanoparticles prepared from lipids solid at room temperature always possess a solid lipid matrix?
Poster, Colloidal Drug Carriers, 1st Expert Meeting, Berlin, Juni 15-17, 1995.

Bunjes H., Westesen K., Koch M.H.J.,
Studies on the incorporation of ubidecarenone into tripalmitin nanoparticle dispersions.
Poster, FIP Conference Stockholm, Schweden, August 28 – September 1, 1995.
Abstract: Book of Abstracts, 162.

Bunjes H., Westesen K., Koch M.H.J.,
Einfluß der Partikelgröße auf Eigenschaften fester Lipidnanopartikel.
Poster, Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Jena, September 21-23, 1995.
Abstract: Book of Abstracts, 164.

Westesen K., Siekmann B., Bunjes H.,
Untersuchungen zur Partikelgrößenverteilung in kolloidalen Lipiddispersionen.
Poster, Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Jena, September 21-23, 1995.
Abstract: Abstractband, 162.

1994

Bunjes H., Westesen K.,
Preparation of solid lipid nanoparticles by two different methods - a comparison.
Poster, 40. Jahrestagung der Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik (APV), Mainz, März 9-12, 1994.
Abstract: Eur. J. Pharm. Biopharm. 40 (Suppl.) 1994, 39S.

Westesen K., Bunjes H., Koch M.H.J.,
Formation of lyotropic liquid crystalline phases of tyloxapol/Triton X100 mixtures with water.
Poster, 40. Jahrestagung der Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik (APV), Mainz, März 9-12, 1994.
Abstract: Eur. J. Pharm. Biopharm. 40 (Suppl.) 1994, 19S.

Westesen K., Bunjes H., Koch M.H.J.,
Phase behaviour of tyloxapol-Triton X100-water-mixtures.
10th International Symposium on Surfactants in Solution, Caracas, Venezuela, Juni 26-30, 1994.
Abstract: Book of Abstracts, 274-275.

Bunjes H., Westesen K., Koch M.H.J.,
Incorporation of ubidecarenone in solid lipid nanoparticles.
Poster, 2nd European Congress of Pharmaceutical Sciences, Berlin, September 29 - Oktober 1, 1994.
Abstract: Eur. J. Pharm. Sci. 2 (1, 2) 1994, 177.

4. Doktorarbeit

Bunjes H.,
Einflussnahme unterschiedlicher Faktoren auf Struktur und Eigenschaften von Nanopartikeln aus festen Triglyceriden,
Dissertation, Friedrich-Schiller-Universität Jena, 1998



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